i think it is a very, very clear that the pendulum of your genetics and your past exposure can alter your susceptibility. i just saw a paper that shows that some of the flame retardants, whether or not you see developmental or toxicity in animal studies, is totally dependent on in the genetics of the mouse and tested in. while mice are not men, they provide us with a great deal of information about what is possible within a population. i think paul is going to talk more about the regulatory agenda. >> i taught chemistry at yale university. one of the things that we always taught our students is that when you introduce a new chemical into the world, when you make chemical and allowed, you need to characterize it. there is a wide range of analyses that are done in order to describe exactly what that chemical is. traditionally, part of that chemical characterization has not included its impact on human health and the environment. as long as that exists, the way you are describing a chemical does not include its impact on humans, on the environment, and developing children, we are going